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Cellular hierarchy and therapy resistance in CSCs The hierarchical model of tumour organisation places CSCs at the apex, with progenitor-like cells and differentiated tumour cells arising from this sub-population [69]

Figure 9A illustrates the operational principle of this aptasensor, where the binding between insulin and aptamers is detected via EIS

De novo design of luciferases using deep learning

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128 Disruption of gut barrier integrity and microbial translocation: The accelerator of liver disease progression Pathophysiological changes in gut barrier structure and function As a key physical and immunological defense line separating intestinal lumen contents from the hosts internal environment, the integrity of the gut barrier suffers systemic destruction during the progression of liver diseases